Background: Cirrhosis of the liver is a progressive chronic illness that leads to significant morbidity and reduced quality of life. Fatigue is among the most distressing symptoms, while inadequate patient knowledge often hampers effective management. Nursing Care Pathways (NCPs) provide structured, evidence-based interventions for improving patient outcomes.

Aim: To evaluate the effectiveness of a Nursing Care Pathway on knowledge and fatigue among patients with cirrhosis of liver admitted in selected hospitals at Erode.

Methodology: An evaluative research approach with pre-test–post-test design was used. The sample included cirrhotic patients admitted under spinal anesthesia. Tools consisted of (i) Demographic data, (ii) Knowledge assessment questionnaire, and (iii) Modified Fatigue Impact Scale (MFIS). Validity and reliability were established (r = 0.94). Ethical approval and informed consent were obtained. Nursing Care Pathway was implemented through structured teaching sessions for the experimental group. Data were analyzed using descriptive and inferential statistics.